Journal of
Diabetes and Endocrinology

  • Abbreviation: J. Diabetes Endocrinol.
  • Language: English
  • ISSN: 2141-2685
  • DOI: 10.5897/JDE
  • Start Year: 2010
  • Published Articles: 71

Full Length Research Paper

The effect of aqueous leaf extract of Adansonia digitata (baobab) on diabetes mellitus and the anterior pituitary of adult male wistar rats

Okorie Pamela
  • Okorie Pamela
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Agu Francis
  • Agu Francis
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Ani Celestine
  • Ani Celestine
  • Department of Human Physiology and Anatomy, College of Medicine, Enugu State University of Science and Technology, Parklane Enugu Nigeria.
  • Google Scholar
Alozie Ifeoma
  • Alozie Ifeoma
  • Department of Human Physiology and Anatomy, College of Medicine, Enugu State University of Science and Technology, Parklane Enugu Nigeria.
  • Google Scholar
Nworgu Choice
  • Nworgu Choice
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Anyaeji Pamela
  • Anyaeji Pamela
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Ugwu Princewill
  • Ugwu Princewill
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Uzoigwe Jide
  • Uzoigwe Jide
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar
Igwe Uzoma
  • Igwe Uzoma
  • Department of Human Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi, Nigeria.
  • Google Scholar
Ejim Nnamdi
  • Ejim Nnamdi
  • Department of Human Physiology and Anatomy, College of Medicine, Enugu State University of Science and Technology, Parklane Enugu Nigeria.
  • Google Scholar
Nwachukwu Daniel
  • Nwachukwu Daniel
  • Department of Human Physiology, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria.
  • Google Scholar


  •  Received: 09 May 2019
  •  Accepted: 19 June 2019
  •  Published: 31 July 2019

References

Akpotu AE, Ani CO, Nworgu C, Okorie P,Igwe U,Uzoigwe J, Igwe U, Adeyemo M,Nwaeme O, Onwujekwe O (2018). Antidiabetic and antihyperlipidemic effects of ethanolic extract of dryopteris dilatat leaves. Journal of Diabetes & Endocrinology 9(3):25-27.
Crossref

 

Bernstein Rk (1980).Virtually continous euglycemia for 5yrs in a labile juvenile onset diabetic patient under non-invasive closed toop control. Diabetes care 3(1):140-143
Crossref

 

Bluestone J, Herold K, Eisenbarth G (2013). Genetics, Pathogenesis and clinical intervention in type 2 diabetes. Nature 464(7293):1293.
Crossref

 

Chen PY, Csutora P, Veyna-Burke NA(1998). Marchase RB.Glucose-6- Phosphatase and Ca2+sequestration are mutually enhanced in microsomes from liver, brain and heart.Diabetes . 47:874-881.
Crossref

 

Chevenne D, Fonfrede M (2007). New diabetes immunoassay specialized. Biology 22(2):95-100
Crossref

 

Chukwuma CO, Fatima A, Nurudden O, Alonge O, Onyinye F, Nwgbara I (2017). Phytochemical, Elemental and proximate analyses of stored sun-dried and shade dried Baobab (Adansonia digitata) leaves. Preprint Converting enzyme inhibitors and angiotensin II receptor blockers on all cause, mortality cardiovascular deaths and cardiovascular events in patients with diabetes mellitus: A meta analyses. JAMA internal medicine 174(5):773-785.

 

David AB (1995). A systemic review of Adansonia digitata leaf. Annals of the Missouri Botanical Garden 82(3):440.
Crossref

 

Eizirik DL, Cnop M (2010). Endoplasmic Reticulum stress in pancreatic beta cells: The thin red line between adaptation and failure. Sci signal 3(110):7.
Crossref

 

Gower BA, Gorec LL, Chandlerlancy PC, Elis AC, Casazza K and Granger WM (2012). A higher-carbohydrate, lower-fat diet reduces fasting glucose concentration and improves beta-cell function in individuals with impaired fasting glucose. Metabolism: 61(3):358-365.
Crossref

 

Harborne JB (1973). Phytochemical Methods: in medicinal plants and traditional medicine in Africa. KLondon Chapman and Hall Limited P 188.

 

Hisayo K, Yukika N, Yatysuya N, Toshihiro T, Kozo H (1996). Secretion of APH in patients with insulin-dependent diabetes mellitus and polyglandular autoimmune syndrome. Internal Medicine 35(9):686-692.
Crossref

 

Jitin R, Manisah J, Manshik K, Shishu PS, Snigh RK, Anuradha AN, Anup K, Raksah kkk (2005). Adansonia digitata L. (baobab): a review of traditional information and taxonomic description. Asian Pacific Journal of Tropical Biomedicine 5(1):79-84.
Crossref

 

Kang X, Wang C, Lifang L, Chen D, Yang Y, Liu G, Wen H, Chen L, He L, Li X, Tian H (2013). Effects of different proportion of carbohydrate in breakfast on postprandial glucose excursion in normal glucose tolerance and impaired glucose regulation subjects. Diabetes technology and therapeutics 15(7):569-574.
Crossref

 

Mamza YP, Udoh AE, Etukudo MH (2013).Evaluation of serum cortisol and growth hormone in type - 2 diabetic subjects attending University of Maiduguri Teaching Hospital Nigeria. IOSR Journal of Dental and Medical Science 7(1):1153-1157.
Crossref

 

Mohammed YG, Hauwahu YB (2013). Hypoglycemic activity of methanolic fruit pulp extract of adansonia digitata on blood glucose levels of alloxan induced diabetic rats. International Journal Animal and Veterinary Advances 5(3):108-113
Crossref

 

Møller N, Jørgensen JO (2009). Effect of growth hormone on glucose, lipid and protein metabolism in human subjects. Endocrinology Review 30:152-177.
Crossref

 

Obadoni BO, Ochuko PO (2001). Phytochemical studies and comparative efficacy of the crude extract of some homeostatic plants in Edo and Delta states of Nigeria. Global Journal of Pure and Applied Sciences 8:203-208.
Crossref

 

Odebiyi OO, Sofowora EA (1978). Phytochemical Screening of Nigeria medicinal plants II. Lioydia 41(3):234-466

 

Saravanaraj OM, Muthusamy P, Radha R, Jerad S (2017). Antidiabetic effect of the ethanolic extract of dried fruit of Adansonia digitata linn. World Journal of Pharmacy and Pharmaceutical Sciences 6(5):1597-1605.
Crossref

 

Sinija VR, Mishra HN (2008). Green tea: Health benefits .Journal of Natural and Environmental Medicine 17(4):232- 242
Crossref

 

Sharangi AB (2009). Medicinal and therapeutic potentials of tea (camellia sinensis L).A Review. Food Research International 42(5-6):529-535.
Crossref

 

Sharma BK, Bhat AA, Jain AK (2015). Adansonia digitata L. (Malvaceae). A threatened tree species of medicinal importance. International Journal of Phytomedicine and Related Industries 7(3)
Crossref

 

Sigurd L (2008). The mechanism of alloxan and streptozotocin-induced diabetes. Diabetologia 51(2):216-226.
Crossref

 

Sofowora A (1993). Medicinal Plants and Traditional Medicine in Africa. Spectrum Books Ltd., Ibadan pp. 191-283.

 

Sung HB, Sang-Wook H, Jaeseok H, Hun-Taeg C. (2012). Endoplasmic Reticulum stress in the B-cell pathogenesis of Type 2 DIabetes. Experimental Diabetes Research 618396 
Crossref

 

Tanko YM, Yerima MA, Mahdi AH (2008). Hypoglycemic activity of methanolic stem bark of Adansonia digitata extract of blood glucose levels of streptozotocin- induced diabetic wistar rats. International Journal of Applied Research and Natural Products 1(2):32-36

 

Trease GE and Evans WC (1989). Pharmacognosy .11th edition, Bailliere Tindal London pp. 45-50.

 

Uotila M, Ruosiahi E, Engrail E (1981). Enzyme linked immune assays. Journal of Immunology 42:11-15

 

Williams MB, Randall GS (2015). Association of diabetes mellitus and disorders of the anterior pituitary, thyroid and adrenal cortex. American Journal of Medicine 7(5):596-608.
Crossref

 

World Health Organisation (WHO) (1980). Second report of WHO expert committee on diabetes mellitus. World Health Organisation Technical Report Series 646, Geneva P 66.

 

Van-Burden TP, Robinson WC (1981). Formation of complexes between protein and tannic acid. Journal of Agriculture and Food Chemistry 1(77).

 

Zagga AL, Abduljabbar IA, Garko M, Tsoho B, Gbande S (2018). Phytochemical composition of Adansonia digitata L. Leaf extracts. Proceedings of the 6th NSCB Biodiversity conferences: Uniuyo pp. 310-314.