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  <front>    <journal-meta>
      <journal-title>Journal of Veterinary Medicine and Animal Health</journal-title>
      <issn pub-type="epub">2141-2529</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JVMAH2017.0573</article-id>
      <title-group>
        <article-title><![CDATA[Observations of oxytetracycline treatment effects in a contagious bovine pleuropneumonia naturally infected herd in Zambia]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Geoffrey</surname>
            <given-names>Munkombwe Muuka</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ana</surname>
            <given-names>Songolo</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Swithine</surname>
            <given-names>Kabilika</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Harvey</surname>
            <given-names>Sikwese</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Benson</surname>
            <given-names>Bowa</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Obrien</surname>
            <given-names>Kabunda</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">geoffreymuuka@yahoo.co.uk</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2017</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>06</month>
        <year>2017</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>14</day>
			<month>03</month>
			<year>2017</year>
		</date>
						<date date-type="accepted">
			<day>24</day>
			<month>04</month>
			<year>2017</year>
		</date>
			  </history>
      <volume>9</volume>
      <issue>6</issue>
	  	  <fpage>110</fpage>
	  <lpage>115</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JVMAH/article-abstract/AEE8E7264297">
		This article is available from http://politicalwaffle.uk/journal/JVMAH/article-abstract/AEE8E7264297	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JVMAH/article-full-text-pdf/AEE8E7264297">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JVMAH/article-full-text-pdf/AEE8E7264297	  </self-uri>
	  
      <abstract><![CDATA[An observational study on the effects of oxytetracycline treatment on contagious bovine pleuropneumonia in a naturally infected herd of 500 cattle was conducted. A total of 68 cattle that showed pneumonia-like clinical signs were treated. Treatment was effected the moment an animal showed signs of illness. A total of 429 cattle were slaughtered after diagnosis of contagious bovine pleuropneumonia and at slaughter, 40.8% (175) had lesions compared to 59.2% (254) that did not have lesions. Out of the total cattle that were treated with oxytetracycline, 57.4% (39) died from contagious bovine pleuropneumonia over a period of 9 weeks while 42.6% (29) survived. Of the treatment group that survived, 37.9% (11) had fibrous lesions indicative of healing, while 62.1% (18) had pathological lesions consistent of active contagious bovine pleuropneumonia (CBPP). Categorisation of carcases with pathological lesions within the treatment group showed 66.7% (12) and 33.3% (6) of acute and chronic lesions, respectively. The CBPP causative agent was isolated through culture and confirmed using polymerase chain reaction (PCR). The results obtained suggest that oxytetracycline did not stop the spread or death of cattle in this particular herd with the treatment of a proportion of the herd. However, large scale field trials are needed in order to validate these findings. It is therefore recommended that any antibiotic that will be developed and advocated for use in the treatment of contagious bovine pleuropneumonia should be effective to contain spread within the herd by treating only a proportion showing signs of the disease.

	Key words: Contagious bovine pleuropneumonia, antibiotics, lung, lesions, oxytetracyline, treatmen, Zambia.]]></abstract>
    </article-meta>
  </front>
      <body/>
    <back>
		<ref-list>
			<title>References</title>
						<ref id="ref1">
				<label>1</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Amanfu W (2009). Contagious Bovine Pleuropneumonia (Lungsickness) in Africa. Onderstepoort J. Vet. Res. 76:14-17.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref2">
				<label>2</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Bashiruddin BJ, Taylor KT, Gould RA (1994). A PCR based test for the specific identification of Mycoplasma mycoides subspecies mycoides SC. J.Vet. Diagn. Invest. 6:428-434.
					h]]>
				</mixed-citation>
			</ref>
						<ref id="ref3">
				<label>3</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Food and Agriculture Organization FAO (2003). towards sustainable CBPP control programmes in Africa. FAO-OIE-AU/IBAR-IAEA consultative Group on Contagious Bovine Pleuropneumonia Third Meeting, Rome. pp.12-14.]]>
				</mixed-citation>
			</ref>
						<ref id="ref4">
				<label>4</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Huebschle BJO, Ayling DR, Godinho K, Lukhele O, Tjipura-Zaire G, Rowan GT, Nicholas RAJR (2006). Danofloxacin (AdvocinTM) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattle. Res. Vet. Sci. 81:304-309.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref5">
				<label>5</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Le Goff C, Thiaucourt F (1998). A competitive ELISA for the specific diagnosis of contagious bovine pleuropneumonia (CBPP). Vet. Microbiol. 60:179-191.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref6">
				<label>6</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Mariner J, Catley A, (2004).The dynamics of CBPP endemism and development of effective control strategies.Proceedings of the third FAO-AU/IBAR-IAEA consultative Group meeting on CBPP in Africa. Rome. pp.76-80.]]>
				</mixed-citation>
			</ref>
						<ref id="ref7">
				<label>7</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Masiga WN, Domenech J, Windsor RS (1986).Manifestation and epidemiology of contagious bovine pleuropneumonia in Africa. Rev. Sci. Tech.15(4):1283-1308.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref8">
				<label>8</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Mitchell DJ, McKellar AQ, McKeever JD (2012). Pharmacodynamics of Antimicrobial against Mycoplasma mycoidesmycoides Small Colony, the causative agent of Contagious Bovine Pleuropneumonia. PLoS ONE 7(8):e44158.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref9">
				<label>9</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Niang M, Sery A, Doucoure M, Kone M, NDiaye M, Amanfu W, Thiaucourt F (2010). Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle. J. Vet. Med. Anim. Health 2(4):35-45.]]>
				</mixed-citation>
			</ref>
						<ref id="ref10">
				<label>10</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Nicholas JAR, Ayling DR, Tjipura-Zaire G, Rowan T (2012). Treatment of Contagious Bovine Pleuropneumonia. Vet. Rec. 171:510-511.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref11">
				<label>11</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Office International des Epizooties (OIE) (2012). Manual of Diagnostic tests and vaccines for Terrestial animals (Mammals, birds and bees). 7:701-716.]]>
				</mixed-citation>
			</ref>
						<ref id="ref12">
				<label>12</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Office International des Epizooties (OIE) (2010). Manual of Diagnostic tests and vaccines for Terrestial animals (Mammals, birds and bees). 6:712-724.]]>
				</mixed-citation>
			</ref>
						<ref id="ref13">
				<label>13</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Provost A, Perreau P, Breard A, le Goff C, Martel JL,Cottew GS (1987). Contagious Bovine Pleuropneumonia. Rev. Sci. Tech 6:625-679.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref14">
				<label>14</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Razin S, Freundt EA (1984).The Mycoplasmas. In: Krieg NR, Holt JG (eds) 67th Bergeys manual of systematic Bacteriology. 1:740-770.]]>
				</mixed-citation>
			</ref>
						<ref id="ref15">
				<label>15</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Scacchia M, Tjipura-Zaire G, Rossella L, Sacchini F,Pini A (2011). Contagious Bovine Pleuropneumonia: humoral and pathological events in cattle infected by endotracheal intubation or by exposure to infected animals. Vet. Ital 47(4):407-413.]]>
				</mixed-citation>
			</ref>
						<ref id="ref16">
				<label>16</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Tambi NE, Maina WO,Ndi C (2006). An estimation of economic impact of Contagious Bovine Pleuropneumonia (CBPP) in Africa. Sci. Tech. Rev. 25:999-1011.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref17">
				<label>17</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Thiaucourt F, Vander Lugt JJ, Provost A (2007).Contagious Bovine Pleuropneumonia. In Coetzer WAJ, Thomson RG, Tustin CR (eds), Infectious Diseases of Livestock with Reference to Southern Africa, 3rdEdition, Oxford University, Press.]]>
				</mixed-citation>
			</ref>
						<ref id="ref18">
				<label>18</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Thomson G (2005). Contagious Bovine Pleuropneumonia and poverty: A strategy for addressing the effects of the disease in sub-Saharan Africa. Research Report DFID Animal Health Programme, Trop. Vet. Med. Uni. Edin. UK.]]>
				</mixed-citation>
			</ref>
						<ref id="ref19">
				<label>19</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Yaya A, Wesonga H, Thiaucourt F (2004). Use of long acting tetracyclines for CBPP-preliminary results.Report of the third meeting of the FAO/OIE/OAU-IBAR consultative group on CBPP, FAO, Rome. pp. 112-113.]]>
				</mixed-citation>
			</ref>
					</ref-list>
	</back>
    </article>