<!DOCTYPE article
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  <front>    <journal-meta>
      <journal-title>Journal of Neuroscience and Behavioral Health</journal-title>
      <issn pub-type="epub">2141-2286</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JNBH2024.0169</article-id>
      <title-group>
        <article-title><![CDATA[Rare presentation of ventricular arteriovenous malformation mimicking tumor lesion in a child: Systematic review and meta-analysis]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Bianca</surname>
            <given-names>F. Pires</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Emanuele</surname>
            <given-names>Pires Canela dos Santos</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Veronica</surname>
            <given-names>Paduam</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Isis</surname>
            <given-names>Franco Martin</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Marcela</surname>
            <given-names>Tanaka Alves de Lima</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Lorena</surname>
            <given-names>Ingegneri Monteiro de Castro</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ana</surname>
            <given-names>Beatriz da Silva lvares</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Carla</surname>
            <given-names>Cristina Barbosa Lopes</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ruy</surname>
            <given-names>Yoshiaki Okaji</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Gabriel</surname>
            <given-names>Rissoli Ramos</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Osmi</surname>
            <given-names>Hamamoto</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">biancafrigopiress@gmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>31</day>
        <month>01</month>
        <year>2025</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>17</day>
			<month>09</month>
			<year>2024</year>
		</date>
						<date date-type="accepted">
			<day>02</day>
			<month>01</month>
			<year>2025</year>
		</date>
			  </history>
      <volume>13</volume>
      <issue>1</issue>
	  	  <fpage>16</fpage>
	  <lpage>22</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JNBH/article-abstract/664458472918">
		This article is available from http://politicalwaffle.uk/journal/JNBH/article-abstract/664458472918	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JNBH/article-full-text-pdf/664458472918">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JNBH/article-full-text-pdf/664458472918	  </self-uri>
	  
      <abstract><![CDATA[Ventricular arteriovenous malformations (AVMs) are rare vascular anomalies characterized by abnormal connections between arteries and veins, bypassing the capillary system. These lesions pose significant diagnostic challenges, particularly when mimicking tumors in pediatric patients. This systematic review with meta-analysis aims to investigate the clinical presentation, diagnostic tools, and treatment outcomes for ventricular AVMs misdiagnosed as tumors in children. Following the PRISMA protocol, a systematic search was conducted in PubMed, Scopus, and Web of Science through October 2024. Inclusion criteria encompassed pediatric cases (0 to 18 years) of ventricular AVMs diagnosed via neuroimaging or angiography. The meta-analysis employed a random-effects model to evaluate the prevalence of diagnostic errors and the relative risk (RR) of unnecessary surgical procedures. Studies with insufficient clinical data or involving only adults were excluded. Out of 60 initially identified studies, 25 met the inclusion criteria. The meta-analysis revealed that 18.7% (95% CI: 14.1 to 23.9) of cases were initially misdiagnosed as tumors. The RR of undergoing unnecessary surgery due to misdiagnosis was 2.45 (95% CI: 1.32 to 4.55; p lt; 0.05). The heterogeneity analysis indicated moderate variability across studies (Isup2; = 68%). Accurate neuroimaging, especially magnetic resonance imaging (MRI) and digital subtraction angiography (DSA), was crucial for distinguishing AVMs from tumors. Ventricular AVMs mimicking tumors are rare but present a high risk of misdiagnosis, leading to inappropriate surgical interventions. This review emphasizes the importance of advanced neuroimaging and a multidisciplinary approach to improve diagnostic accuracy and treatment outcomes. Future research should focus on refining diagnostic protocols and exploring minimally invasive treatment strategies for these complex cases.

	Key words: Ventricular arteriovenous malformation, ventricular tumor, pediatric tumor.]]></abstract>
    </article-meta>
  </front>
      <body/>
    <back>
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