<!DOCTYPE article
  PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="2.0" xml:lang="EN">
  <front>    <journal-meta>
      <journal-title>Journal of Developmental Biology and Tissue Engineering</journal-title>
      <issn pub-type="epub">2141-2251</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JDBTE.9000005</article-id>
      <title-group>
        <article-title><![CDATA[Fibrin sealant as scaffold can be a suitable substitute to autograft in short peripheral nerve defect in rats]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        	          <name name-style="western">
            <surname>Z.</surname>
            <given-names>Jamalpoor</given-names>
          </name>
                    <name name-style="western">
            <surname>M.</surname>
            <given-names>Ebrahimi</given-names>
          </name>
                    <name name-style="western">
            <surname>N.</surname>
            <given-names>Amirizadeh</given-names>
          </name>
                    <name name-style="western">
            <surname>K.</surname>
            <given-names>Mansoori</given-names>
          </name>
                    <name name-style="western">
            <surname>A.</surname>
            <given-names>Asgari</given-names>
          </name>
                    <name name-style="western">
            <surname>M.</surname>
            <given-names>R. Nourani</given-names>
          </name>
                    <name name-style="western">
            <surname></surname>
            <given-names></given-names>
          </name>
                  </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">r.nourani@yahoo.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2011</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>06</month>
        <year>2011</year>
      </pub-date>
      <history>
      					<date date-type="accepted">
			<day>22</day>
			<month>04</month>
			<year>2011</year>
		</date>
			  </history>
      <volume>3</volume>
      <issue>6</issue>
	  	  <fpage>75</fpage>
	  <lpage>79</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JDBTE/article-abstract/B758E1010466">
		This article is available from http://politicalwaffle.uk/journal/JDBTE/article-abstract/B758E1010466	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JDBTE/article-full-text-pdf/B758E1010466">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JDBTE/article-full-text-pdf/B758E1010466	  </self-uri>
	  
      <abstract><![CDATA[There is considerable evidence that peripheral nerves have the potential to regenerate in an appropriate microenvironment. In this study, the process of nerve regeneration through a fibrin scaffold was examined. 45 male Wistar rats were randomly divided into one control, Autograft (Auto) and two experimental groups, Epineurum (Epi) and Fibrin scaffold (Fib). Right sciatic nerve was exposed of which 5 mm was cut. The nerve defect was then bridged with a nerve autograft, empty epineurium and fibrin scaffold in the corresponding groups. All animals were examined one, three and five weeks after the operation to evaluate nerve regeneration and functional recovery employing light microscopy and walking track analysis, respectively. The gastrocnemius muscle contractility was also examined at 35th day post surgery in all groups using electromyography (EMG). Histological, functional evaluation and EMG evidences show that the nerve regeneration in both groups Auto and Fib were statistically equivalent  and superior to that of Epi group (Plt;0.01). The present findings indicate that a fibrin scaffold enhances nerve regeneration as effective as a nerve autograft.

	 

	Key words: Sciatic nerve, fibrin scaffold, electromyography, autograft.]]></abstract>
    </article-meta>
  </front>
  </article>