<!DOCTYPE article
  PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="2.0" xml:lang="EN">
  <front>    <journal-meta>
      <journal-title>Journal of Developmental Biology and Tissue Engineering</journal-title>
      <issn pub-type="epub">2141-2251</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JDBTE.9000024</article-id>
      <title-group>
        <article-title><![CDATA[Synthesis, characterization and biological activity of some novel azetidinones]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        	          <name name-style="western">
            <surname>A.</surname>
            <given-names>Rajasekaran</given-names>
          </name>
                    <name name-style="western">
            <surname>M.</surname>
            <given-names>Periasamy</given-names>
          </name>
                    <name name-style="western">
            <surname>S.</surname>
            <given-names>Venkatesan</given-names>
          </name>
                  </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">rsekaran2001in@yahoo.co.in</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2010</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>06</month>
        <year>2010</year>
      </pub-date>
      <history>
      					<date date-type="accepted">
			<day>23</day>
			<month>10</month>
			<year>2009</year>
		</date>
			  </history>
      <volume>2</volume>
      <issue>1</issue>
	  	  <fpage>5</fpage>
	  <lpage>13</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JDBTE/article-abstract/5D3660610349">
		This article is available from http://politicalwaffle.uk/journal/JDBTE/article-abstract/5D3660610349	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JDBTE/article-full-text-pdf/5D3660610349">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JDBTE/article-full-text-pdf/5D3660610349	  </self-uri>
	  
      <abstract><![CDATA[A series of seven novel azetedinones 4a-g have been synthesized by cyclocondensation of various Schiff bases of phenothiazine with chloroacetyl chloride in presence of triethylamine. Various Schiff bases of phenothiazine were synthesized by condensation of 2-hydrazinyl-1-(10H-phenothiazin-10-yl)ethanone 2 with various aryl aldehydes. Compound 2 was synthesized by reacting 2-chloro-1-(10H-phenothiazin-10-yl) ethanone 1 with hydrazine hydrate. The synthesized compounds were characterized by IR, 1H-NMR and mass spectra. The titled compounds were evaluated for anti-tubercular, anti-bacterial, anti-fungal and anti-inflammatory activity by Lowenstein-Jensen medium method, cup plate method, disc diffusion method and carrageenan induced paw edema method, respectively. All the seven compounds 4a-g at a concentration of 100, 10 and 1 mg/L showed inhibition against the growth of Mycobacterium tuberculosis. Compounds showed good anti-bacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 4e showed equipotent antibacterial activity with streptomycin standard and showed better anti-bacterial activity against gram positive bacteria profile than gram negative bacteria. Zone of inhibition was not found for the compounds against Escherichia coli and Pseudomonas aeruginosa. Compounds 4a-g exhibited good antifungal activity against Aspergillus species and no activity against Candida albicans. None of the reported compounds showed promising anti-inflammatory activity.

	Key words: Azetidinones, anti-tubercular, anti-bacterial, anti-fungal, inflammation]]></abstract>
    </article-meta>
  </front>
  </article>