<!DOCTYPE article
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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="2.0" xml:lang="EN">
  <front>    <journal-meta>
      <journal-title>Scientific Research and Essays</journal-title>
      <issn pub-type="epub">1992-2248</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/SRE2018.6590</article-id>
      <title-group>
        <article-title><![CDATA[Honey activity on the proliferation and migration of oral squamous cell carcinoma: In vitro and bioinformatic analysis]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Eliane</surname>
            <given-names>Macedo Sobrinho Santos</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Hercules</surname>
            <given-names>Otaclio Santos</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Juliana</surname>
            <given-names>Rezende Sa Miranda Goncalves</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Anna</surname>
            <given-names>Christina Almeida</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Igor</surname>
            <given-names>Viana Brandi</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Alex</surname>
            <given-names>Sander Rodrigues Cangussu</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Janainne</surname>
            <given-names>Nunes Alves</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Sabrina</surname>
            <given-names>Ferreira de Jesus</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ricardo</surname>
            <given-names>Jardim Neiva</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Kattyanne</surname>
            <given-names>de Souza Costa</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Andre</surname>
            <given-names>Luiz Sena Guimaraes</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Lucyana</surname>
            <given-names>Conceiao Farias</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">elianemsobrinho@hotmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2018</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>15</day>
        <month>10</month>
        <year>2018</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>11</day>
			<month>09</month>
			<year>2018</year>
		</date>
						<date date-type="accepted">
			<day>11</day>
			<month>10</month>
			<year>2018</year>
		</date>
			  </history>
      <volume>13</volume>
      <issue>15</issue>
	  	  <fpage>158</fpage>
	  <lpage>171</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/SRE/article-abstract/60EC8D659093">
		This article is available from http://politicalwaffle.uk/journal/SRE/article-abstract/60EC8D659093	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/SRE/article-full-text-pdf/60EC8D659093">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/SRE/article-full-text-pdf/60EC8D659093	  </self-uri>
	  
      <abstract><![CDATA[This study aimed to investigate, in oral squamous carcinoma cells (OSCC), the  antineoplastic effect of Apis mellifera honey produced from Aroeira and wildflower, in the region of Jequitinhonha River Valley, Brazil. Furthermore, we investigate the molecular mechanism of honey performance through bioinformatic analysis. Honey and OSCC-related gene list were screened using GeneCards. The online tool STRING was used to identify the potential interaction networks of protein products of these genes. The genes with the highest weighted number of links (WNL) were called leader genes. GO and KEGG pathway analysis was performed to classify the genes. We use a search tool STITCH for interactions of chemicals-proteins. The chemical characterization of honey and its antiproliferative and antimigratory effects in SCC-9 cell lines was evaluated in vitro. The analysis of the interaction network obtained from the STRING database indicated by the following leader genes: TNF, IL6 and HDAC1. GO analysis for the honey, and OSCC-related proteins revealed that leader genes-regulated cancers genes were markedly enriched in some functions. Through the chemical characterization, the bioactive classes: steroids/triterpenoids, flavonoids, saponins, alkaloids, and tannins were identified. Polyphenols act in activating CASP3 and TP53 and inhibit the action of DNMT1. The honey produced from Aroeira and wildflower reduced proliferative phenotype and migration of OSCC cells.

	Key words: Aroeira honey, Myracrodruon urundeuva, wild honey, Apis mellifera, therapeutic, Jequitinhonha River Valley.]]></abstract>
    </article-meta>
  </front>
      <body/>
    <back>
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