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  <front>    <journal-meta>
      <journal-title>Journal of Pharmacognosy and Phytotherapy</journal-title>
      <issn pub-type="epub">2141-2502</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JPP2022.0619</article-id>
      <title-group>
        <article-title><![CDATA[Antitumoral effect of Striga hermonthica (Delile) Benth. methanolic extract is mediated by alterations on procaspase-3 and cyclin B expression in prostate cancer cell lines]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Mindidiba</surname>
            <given-names>Jean BANGOU</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Tangbadioa</surname>
            <given-names>Herv COULIDIATI</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Aminata</surname>
            <given-names>P NACOULMA</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Abdoulaye</surname>
            <given-names>SEGDA</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Emmanuel</surname>
            <given-names>AM THIOMBIANO</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Georges</surname>
            <given-names>Anicet OUEDRAOGO</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">mindiediba.bangou@u-naziboni.bf</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>04</month>
        <year>2022</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>21</day>
			<month>01</month>
			<year>2022</year>
		</date>
						<date date-type="accepted">
			<day>16</day>
			<month>03</month>
			<year>2022</year>
		</date>
			  </history>
      <volume>14</volume>
      <issue>1</issue>
	  	  <fpage>1</fpage>
	  <lpage>7</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JPP/article-abstract/B11124869030">
		This article is available from http://politicalwaffle.uk/journal/JPP/article-abstract/B11124869030	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JPP/article-full-text-pdf/B11124869030">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JPP/article-full-text-pdf/B11124869030	  </self-uri>
	  
      <abstract><![CDATA[Cancer is one of the major public health problems of the 21st century. Its incidence is increasing in both developed and low-income countries. This trend is justified by the change in people#39;s lifestyles. Cancer of the prostate is one of major cancer types affecting male population. The present study focused on the use of methanolic extract of Striga hermonthica (Delile) Benth. to evaluate total phenolics and flavonoids contents, antioxidant activities, anti-proliferative and anti-migratory effects, using ATCC prostate cancer cell lines (22RV1, DU145, C4-2 and RWPE-1). Total phenolics and flavonoids content were estimated using spectrophotometric methods. Antioxidant potential was evaluated using three methods while cytotoxicity assay, anti-migratory assay and western blot analysis were used for the determination of extracts anti-proliferative activity on prostate cancer cells. Therefore, to assess apoptosis induction in prostate cancer cell lines, the effect of S. hermonthica (Delile) Benth. methanolic extract was investigated on procaspase-3, procaspase-8, and cyclin-B2 expression. A range of half-dilution concentrations beginning from 500  g/mL have been prepared to determine the IC50 in the various tests. Antioxidant compounds were shown to be promising biomolecules, with particular interest in cancer management. Among plant derivative compounds, phenolics and derived molecules have endorsed antioxidant capacities and potential anti-proliferative activities. The best inhibition was obtained on C4-2 cells with an IC50 = 65.76  g/mL and a selectivity index of 2.35. The results obtained from this study could partially justify the traditional indications of this plant in the treatment of prostate cancer.

	Key words: Plant derived products, anti-tumoral, prostate cancer, antioxidants.]]></abstract>
    </article-meta>
  </front>
      <body/>
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