<!DOCTYPE article
  PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" dtd-version="2.0" xml:lang="EN">
  <front>    <journal-meta>
      <journal-title>Journal of Pharmacognosy and Phytotherapy</journal-title>
      <issn pub-type="epub">2141-2502</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JPP2025.0645</article-id>
      <title-group>
        <article-title><![CDATA[Antimalarial effects of Diospyros chamaethamnus and Guibourtia coleosperma extracts in mice with Plasmodium berghei malaria]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Charwan</surname>
            <given-names>Iwanette du Preez-Bruwer</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Davis</surname>
            <given-names>Ropafadzo Mumbengegwi</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">ibruwer@unam.na</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2025</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>04</month>
        <year>2025</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>30</day>
			<month>04</month>
			<year>2025</year>
		</date>
						<date date-type="accepted">
			<day>08</day>
			<month>05</month>
			<year>2025</year>
		</date>
			  </history>
      <volume>17</volume>
      <issue>2</issue>
	  	  <fpage>12</fpage>
	  <lpage>28</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JPP/article-abstract/926F74473313">
		This article is available from http://politicalwaffle.uk/journal/JPP/article-abstract/926F74473313	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JPP/article-full-text-pdf/926F74473313">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JPP/article-full-text-pdf/926F74473313	  </self-uri>
	  
      <abstract><![CDATA[The development of effective antimalarials remains crucial due to ineffective treatments, increasing drug resistance, and restricted access to these drugs in resource-poor malaria-endemic countries. This study aimed to investigate the efficacy of Diospyros chamaethamnus and Guibourtia coleosperma based on their traditional uses. Efficacy of the extracts was evaluated against Plasmodium berghei in Swiss albino mice using suppressive and prophylactic tests. The plant extracts were also tested for toxicity in healthy mice, beginning  with a dose of 300 mg/kg. The plant extracts demonstrated antiplasmodial activity at an 800 mg/kg dose, with D. chamaethamnus showing 44.66% and G. coleosperma 29.59%. This dose prolonged the survival of the mice post-infection by 50 and 58%, respectively, compared to control untreated mice (Plt;0.05). Aqueous extracts (800 mg kg-1) of D. chamaethamnus and G. coleosperma showed prophylactic activities, reducing parasite load by 56.13 and 55.48%, respectively. No mortalities or adverse effects were observed in the mice, indicating that the extracts were not toxic. According to the findings, the two plants show promise as alternative malaria treatment options.

	Key words: Malaria, antiplasmodial activity, suppressive test, repository test, acute oral toxicity, Diospyros chamaethamnus, Guibourtia coleosperma, Namibia.]]></abstract>
    </article-meta>
  </front>
      <body/>
    <back>
		<ref-list>
			<title>References</title>
						<ref id="ref1">
				<label>1</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Abubakar AR, Haque M (2020). Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes. Journal of Pharmacy and Bioallied Sciences 12:1-10.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref2">
				<label>2</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Akintola AO, Kehinde BD, Ayoola PB, Ibikunle GJ, Oyewande EA, Arotayo RA, Bell, MO (2022). Antimalarial activity of the crude extract and solvent fractions of the stem of Momordica charantia in Plasmodium berghei infected mice. Journal of Communicable Diseases 5(3):37-47.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref3">
				<label>3</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Alli LA, Adesokan AA, Salawu AO (2016). Antimalarial activity of fractions of aqueous extract of Acacia nilotica root. Journal of Intercultural Ethnopharmacology 5(2):180.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref4">
				<label>4</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Amoa Ongun P, Ntie-Kang F, Lifongo LL, Ndom JC, Sippl W, Mbaze LMA (2013). The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids. Malaria Journal 12:1-26.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref5">
				<label>5</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Arrey Tarkang P, Okalebo FA, Ayong LS, Agbor GA, Guantai AN (2014). Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models. Malaria Journal 13:1-11.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref6">
				<label>6</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Arrow KJ, Panosian C, Gelband H (2004). The Human and Economic Burden of Malaria. National Academies Press (US).
				
					View]]>
				</mixed-citation>
			</ref>
						<ref id="ref7">
				<label>7</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Bekono BD, Ntie-Kang F, Ongun PA, Lifongo LL, Sippl W, Fester K, Owono LC (2020). The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019. Malaria Journal 19:1-35.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref8">
				<label>8</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Bitombo AN, Zintchem AAA, Atchad ADT, Nyemeck IiNM, Bikobo DSN, Pegnyemb DE, Bochet CG (2021). Antiplasmodial activities of indole alkaloids from Tabernaemontana penduliflora K. Schum (Apocynaceae). Fitoterapia 153:104941.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref9">
				<label>9</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Boampong JN, Karikari AA, Ameyaw EO (2015). In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri. Asian Pacific Journal of Tropical Biomedicine 5(6):446-450.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref10">
				<label>10</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Bommakanti V, Puthenparambil Ajikumar A, Sivi CM, Prakash G, Mundanat AS, Ahmad F, Rana SS (2023). An overview of herbal nutraceuticals, their extraction, formulation, therapeutic effects and potential toxicity. Separations 10(3):177.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref11">
				<label>11</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Borges A, Jos H, Homem V, Simes M (2020). Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea. Antibiotics 9(2):48.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref12">
				<label>12</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Castelli F, Odolini S, Autino B, Foca E, Russo R (2010). Malaria prophylaxis: a comprehensive review. Pharmaceuticals 3(10):3212-3239.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref13">
				<label>13</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Christian AG, Akanimo EG, Ahunna AG, Nwakaego EM, Chimsorom CK (2014). Antimalarial potency of the methanol leaf extract of Maerua crassifolia Forssk (Capparaceae). Asian Pacific Journal of Tropical Disease 4(1):35-39.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref14">
				<label>14</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Chuma J, Okungu V, Molyneux C (2010). Barriers to prompt and effective malaria treatment among the poorest population in Kenya. Malaria Journal 9:144.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref15">
				<label>15</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Deharo E, Bourdy G, Quenevo C, Munoz V, Ruiz G, Sauvain M (2001). A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians. Journal of Ethnopharmacology 77(1):91-98.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref16">
				<label>16</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Dhiman S (2019). Are malaria elimination efforts on right track? An analysis of gains achieved and challenges ahead. Infectious Diseases of Poverty 8:1-19.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref17">
				<label>17</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Du Preez I, Louw S, Mumbengegwi DR (2020). Chemical Composition and Inhibitory Effects of Guibourtia coleosperma against Plasmodium Parasites In Vitro. In: African Natural Plant Products, Volume III: Discoveries and Innovations in Chemistry, Bioactivity, and Applications. American Chemical Society pp. 153-170.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref18">
				<label>18</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[du Preez-Bruwer I, Mumbengegwi DR, Louw S (2022). In vitro antimalarial properties and chemical composition of Diospyros chamaethamnus extracts. South African Journal of Botany 149:290-296.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref19">
				<label>19</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Dushimemaria F, Du Preez CI, Mumbengegwi DR (2017). Randomized anticancer and cytotoxicity activities of Guibourtia coleosperma and Diospyros chamaethamnus. African Journal of Traditional Complementary Alternative Medicine 14:1-7.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref20">
				<label>20</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Graz B, Kitua AY, Malebo HM (2011). To what extent can traditional medicine contribute a complementary or alternative solution to malaria control programmes? Malaria Journal 10:1-7.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref21">
				<label>21</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Hartung T (2024). The (misleading) role of animal models in drug development. Frontiers in Drug Discovery 4:1355044.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref22">
				<label>22</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Ikuno E, Matsumoto T, Okubo T, Itoi S, Sugita H (2008). Difference in the sensitivity to chemical compounds between female and male neonates of Daphnia magna. Environmental Toxicology: An International Journal 23(5):570-575.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref23">
				<label>23</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Kayiba NK, Yobi DM, Devleesschauwer B, Mvumbi DM, Kabututu PZ, Likwela JL, Speybroeck N (2021). Care-seeking behaviour and socio-economic burden associated with uncomplicated malaria in the Democratic Republic of Congo. Malaria Journal 20(1):260.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref24">
				<label>24</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Lajoie L, Fabiano-Tixier AS, Chemat F (2022). Water as green solvent: methods of solubilisation and extraction of natural products-past, present and future solutions. Pharmaceuticals 15(12):1507.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref25">
				<label>25</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Langhorne J, Quin SJ, Sanni LA (2002). Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology. Chemical Immunology 80(80):204-228.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref26">
				<label>26</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Mina PR, Kumar Y, Verma AK, Khan F, Tandon S, Pal A, Darokar MP (2020). Silymarin, a polyphenolic flavonoid impede Plasmodium falciparum growth through interaction with heme. Natural Product Research 34(18):2647-2651.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref27">
				<label>27</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Ministry of Health and Social Services (2017). Namibia Malaria Strategic Plan 2017-2022. Ministry of Health and Social Services of Namibia, Windhoek, Namibia. This document is not electronically available; only hard copies are available.]]>
				</mixed-citation>
			</ref>
						<ref id="ref28">
				<label>28</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Mukherjee P, Roy S, Ghosh D, Nandi SK (2022). Role of animal models in biomedical research: a review. Laboratory Animal Research 38(1):18.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref29">
				<label>29</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Nafiu MO, Abdulsalam TA, Akanji MA (2013). Phytochemical analysis and antimalarial activity aqueous extract of Lecaniodiscus cupanioides root. Journal of Tropical Medicine 2013(1):605393.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref30">
				<label>30</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Nafuka SN (2014). In Vitro Antiplasmodial activity and phytochemicals screening of ethnomedicinal plants used to treat Malaria associated symptoms.]]>
				</mixed-citation>
			</ref>
						<ref id="ref31">
				<label>31</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Nafuka SN, Mumbengegwi DR (2014). Phytochemical analysis and in vitro anti-plasmodial activity of selected ethnomedicinal plants used to treat malaria associated symptoms in Northern Namibia. International Science and Technology Journal of Namibia pp. 078-093.]]>
				</mixed-citation>
			</ref>
						<ref id="ref32">
				<label>32</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Njateng GSS, Gatsing D, Mouokeu RS, Lunga PK, Kuiate JR (2013). In vitro and in vivo antidermatophytic activity of the dichloromethane-methanol (1: 1 v/v) extract from the stem bark of Polyscias fulva Hiern (Araliaceae). BMC Complementary and Alternative Medicine 13:1-10.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref33">
				<label>33</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[OECD (2002). OECD Guidelines for the Testing of Chemicals, Section 4. In: Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure. Organisation for Economic Co-operation and Development, Paris.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref34">
				<label>34</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Omagha R, Idowu ET, Alimba CG, Otubanjo OA, Oyibo WA, Agbaje EO (2021). In vivo antiplasmodial activities and acute toxicity assessment of two plant cocktail extracts commonly used among Southwestern Nigerians. Journal of Parasitic Diseases pp. 1-11.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref35">
				<label>35</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Onwujekwe O, Uguru N, Etiaba E, Chikezie I, Uzochukwu B, Adjagba A (2013). The economic burden of malaria on households and the health system in Enugu State southeast Nigeria. PloS one 8(11):e78362.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref36">
				<label>36</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Orok AB, Ajibaye O, Aina OO, Iboma G, Adagyo Oboshi S, Iwalokun B (2021). Malaria interventions and control programes in Sub-Saharan Africa: A narrative review. Cogent Medicine 8(1):1940639.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref37">
				<label>37</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Otieno JN, Hosea KMM, Lyaruu HV, Mahunnah RLA (2008). Multi-plant or single-plant extracts, which is the most effective for local healing in Tanzania?. African Journal of Traditional, Complementary and Alternative Medicines 5(2):165-172.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref38">
				<label>38</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Ouji M, Augereau JM, Paloque L, Benoit-Vical F (2018). Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination. Parasite Paris France 25:24.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref39">
				<label>39</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Pandey A, Tripathi SM (2014). Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. Journal of Pharmacognosy and phytochemistry 2(5):115-119]]>
				</mixed-citation>
			</ref>
						<ref id="ref40">
				<label>40</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Parvatkar PT, Diagne K, Zhao Y, Manetsch R (2024). Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities. ChemMedChem 19:e202400254.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref41">
				<label>41</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Phuwajaroanpong A, Chaniad P, Plirat W, Phoopha S, Septama AW, Chukaew A, Punsawad C (2022). Antiplasmodial properties of aqueous and ethanolic extracts of ten herbal traditional recipes used in Thailand against Plasmodium falciparum. Tropical Medicine and Infectious Disease 7(12):417.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref42">
				<label>42</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Plaskova A, Mlcek J (2023). New insights of the application of water or ethanol-water plant extract rich in active compounds in food. Frontiers in Nutrition 10:1118761.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref43">
				<label>43</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Prachayasittikul S, Saraban P, Cherdtrakulkiat R, Ruchirawat S, Prachayasittikul V (2010). New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. Excli Journal 9:1.]]>
				</mixed-citation>
			</ref>
						<ref id="ref44">
				<label>44</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Quattrocchi U (2016). CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology (5 Volume Set). CRC Press.]]>
				</mixed-citation>
			</ref>
						<ref id="ref45">
				<label>45</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Shretta R, Liu J, Cotter C (2017). Malaria Elimination and Eradication. In: Holmes KK, Bertozzi S, Bloom BR, Jha P (eds.), Major Infectious Diseases, 3rd edition. The International Bank for Reconstruction and Development / The World Bank, Washington (DC).
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref46">
				<label>46</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Simba DO, Kakoko D, Nyamhanga T, Mrango Z, Mujinja P (2018). Improving prompt access to malaria diagnostics and treatment in rural remote areas using financial benefit for community health workers in Kilosa district, Tanzania. Research and Reports in Tropical Medicine pp. 137-146.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref47">
				<label>47</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Smith JL, Mumbengegwi D, Haindongo E, Cueto C, Roberts KW, Gosling R, Sturrock HJ (2021). Malaria risk factors in northern Namibia: the importance of occupation, age and mobility in characterizing high-risk populations. PLoS One 16(6):e0252690.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref48">
				<label>48</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Titanji VP, Zofou D, Ngemenya MN (2008). The antimalarial potential of medicinal plants used for the treatment of malaria in Cameroonian folk medicine. African Journal of Traditional, Complementary and Alternative Medicines 5(3):302.]]>
				</mixed-citation>
			</ref>
						<ref id="ref49">
				<label>49</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Traore O, Ouedraogo A, Compaore M, Nikiema K, Zombre A, Kiendrebeogo M, Duez P (2021). Social perceptions of malaria and diagnostic-driven malaria treatment in Burkina Faso. Heliyon 7(1).
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref50">
				<label>50</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Vaou N, Stavropoulou E, Voidarou C, Tsakris Z, Rozos G, Tsigalou C, Bezirtzoglou E (2022). Interactions between medical plant-derived bioactive compounds: Focus on antimicrobial combination effects. Antibiotics 11(8):1014.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref51">
				<label>51</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[Wanyoike GN, Chhabra SC, Langat-Thoruwa CC, Omar SA (2004). Brine shrimp toxicity and antiplasmodial activity of five Kenyan medicinal plants. Journal of ethnopharmacology 90(1):129-133.
					]]>
				</mixed-citation>
			</ref>
						<ref id="ref52">
				<label>52</label>
				<mixed-citation publication-type="other" xlink:type="simple">
				<![CDATA[World Health Organization (2023). World Malaria Report 2023. World Health Organization, Geneva.
				
					View]]>
				</mixed-citation>
			</ref>
					</ref-list>
	</back>
    </article>