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  <front>    <journal-meta>
      <journal-title>Journal of Clinical Medicine and Research</journal-title>
      <issn pub-type="epub">2141-2235</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/JCMR11.041</article-id>
      <title-group>
        <article-title><![CDATA[Liquid nitrogen cryotherapy vs. Betamethasone lotion in the management of Alopecia areata]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Faghihi</surname>
            <given-names>Gita</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Radan</surname>
            <given-names>Mohammadreza</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">g_faghihi@med.mui.ac.ir</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2013</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>28</day>
        <month>02</month>
        <year>2013</year>
      </pub-date>
      <history>
      					<date date-type="accepted">
			<day>25</day>
			<month>10</month>
			<year>2013</year>
		</date>
			  </history>
      <volume>5</volume>
      <issue>2</issue>
	  	  <fpage>18</fpage>
	  <lpage>22</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JCMR/article-abstract/6BE46595156">
		This article is available from http://politicalwaffle.uk/journal/JCMR/article-abstract/6BE46595156	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/JCMR/article-full-text-pdf/6BE46595156">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/JCMR/article-full-text-pdf/6BE46595156	  </self-uri>
	  
      <abstract><![CDATA[Alopecia areata (AA) is a common disease of hair follicles. Cryotherapy has been employed to stimulate hair regrowth. We decided to evaluate the efficacy of this method in patchy AA. Forty patients of age gt;5 years and with 120 recalcitrant patches were enrolled in this study. AA had covered less than 25% of patientsrsquo; scalps. In each individual, one lesion was treated with nitrogen cryotherapy once weekly for a period of 6 weeks; meanwhile another lesion was treated with topical 0.1% betamethasone lotion. All patients were followed up from weeks 2 to 14. Thirty-nine out of forty patients completed therapy. The overall response rate was 88% for patches treated with cryotherapy and 90% for patches treated with betamethasone lotion. Complete recovery (gt;90% terminal hair growth) was not obtained in any patient.  Chi-square test showed no significant difference between improvements of alopecia in the two groups (reliability 95%). Pearson measurement showed a significant reverse relationship between diameter and duration of patches and the improvement rate in both groups. Liquid nitrogen cryotherapy can be a helpful modality in the treatment of AA.

	 

	Key words:  Alopecia areata, treatment, liquid nitrogen cryotherapy, betamethasone lotion.]]></abstract>
    </article-meta>
  </front>
  </article>