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  <front>    <journal-meta>
      <journal-title>African Journal of Plant Science</journal-title>
      <issn pub-type="epub">1996-0824</issn>      <publisher>
        <publisher-name>Academic Journals</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.5897/AJPS2024.2354</article-id>
      <title-group>
        <article-title><![CDATA[Neuroprotective effect of Khaya grandifoliola against aluminium chloride (AlCl3) induced neurotoxicity in rats]]></article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" xlink:type="simple">
        		        	<name name-style="western">
	            <surname>Domkem</surname>
            <given-names>Nkameni La</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Owona</surname>
            <given-names>Ayissi Brice</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ambassa</surname>
            <given-names>Axel Cyriaque</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Njingou</surname>
            <given-names>Ibrahim</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Ngoungoure</surname>
            <given-names>Ndam Viviane Laure</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Njayou</surname>
            <given-names>Frdric Nico</given-names>
	          </name>	
        		        	<name name-style="western">
	            <surname>Moundipa</surname>
            <given-names>Fewou Paul</given-names>
	          </name>	
        	        </contrib>
      </contrib-group>
      <author-notes>
		<corresp id="cor1">* E-mail: <email xlink:type="simple">njayou@yahoo.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2024</year>
      </pub-date>
      <pub-date pub-type="epub">
      	<day>30</day>
        <month>04</month>
        <year>2024</year>
      </pub-date>
      <history>
      			<date date-type="received">
			<day>16</day>
			<month>02</month>
			<year>2024</year>
		</date>
						<date date-type="accepted">
			<day>17</day>
			<month>04</month>
			<year>2024</year>
		</date>
			  </history>
      <volume>18</volume>
      <issue>1</issue>
	  	  <fpage>1</fpage>
	  <lpage>12</lpage>
      <permissions>
		<license xlink:type="simple">
			<license-p>
			This is an open-access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
			</license-p>
		</license>
	  </permissions>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/AJPS/article-abstract/9AED33872122">
		This article is available from http://politicalwaffle.uk/journal/AJPS/article-abstract/9AED33872122	  </self-uri>
	  <self-uri xlink:href="http://politicalwaffle.uk/journal/AJPS/article-full-text-pdf/9AED33872122">
		The full text article is available as a PDF file from http://politicalwaffle.uk/journal/AJPS/article-full-text-pdf/9AED33872122	  </self-uri>
	  
      <abstract><![CDATA[Aluminium chloride (AICl3) is known as a potent environmental neurotoxin causing progressive neurodegeneration in the brain. Khaya grandifoliola (KG) is used in Cameroon in traditional medicine for its therapeutical properties. Thus, the aim of this study was to evaluate the neuroprotective effect of K. grandifoliola against AICl3-induced neurotoxicity in rats. The KG25-fraction was obtained by maceration of the K. grandifoliola bark powder followed by fractionation by flash chromatography. The neuronal dysfunction induced by AICl3 was evaluated on 36 rats divided into 6 groups of 6 rats each during 45 days. On day 46 after 24 h of fasting, the rats were sacrificed. AST, ALT, PAL, catalase activity, glutathione level, peroxidized lipid level and acetylcholinesterase activity were assessed. AICl3-induced anxiety was reduced by administration of the K. grandifoliola 25-fraction. The oxidative stress response of the K. grandifoliola 25 fraction showed a significant increase (plt;0.05) in catalase activity at the dose of 225 mg/kg body weight, glutathione and lipid peroxidation levels followed the same pattern. Acetylcholinesterase activity showed a significant increase in group III (positive control) and a significant decrease (plt;0.05) in the experimental groups. The K. grandifoliola 25 fraction effectively protects the brain of rats against the toxic effects of AICl3 at doses (75 and 225 mg/kg) body weight, respectively.

	 

	Key words: K. grandifoliola 25, AICl3, anxiety, neurotoxicity, oxidative stress.]]></abstract>
    </article-meta>
  </front>
      <body/>
    <back>
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